For roughly a one hundred fifty pesos ($3.85 US) you can get from one city to the next. I have personally utilized the bus service to travel from Sosua to Santiago and Santiago to Santo Domingo and prefer this mode of transportation because it's a great way to see the sites along the way without having the distractions of being behind the wheel of a rental car, not to mention it's a relaxing comfortable ride that allows you to catch up on your sleep if you stayed out to late in the discos or clubs the night before. There are several bus companies operating in the Dominican Republic, but I recommend using Caribe Tours.

Caribe Tours offers modern style equipment much like you would find with Greyhound in the USA. Additionally, you will find a Caribe Tours Bus terminal in almost every city in the Dominican Republic, currently providing services to over 35 cities. Almost every local resident or taxi driver will know where the nearest Caribe Tours bus terminal is, even if you speak little to no Spanish you will not find it difficult to purchase a ticket at the terminal or station. To make the best use of your time and avoid longer waiting times at the terminal you can view the bus schedule with departure times online at http://www.caribetours.com.do. However, it might be helpful if you can read Spanish to view this website. Metro Tours and Terra Bus also provide bus service between selected cities in the Dominican Republic.